Which fictional address does House M.D. give for Gregory House’s home?

House M.D. gives Gregory House’s home address as 221B Baker Street.

The address is a direct reference to 221B Baker Street, the famous London home of Sherlock Holmes. House’s character was deliberately modeled in part on Holmes, especially in his use of deduction, his unconventional methods, and his reliance on a close friend who challenges him.

The address appears as an in-universe detail even though House lives and works in New Jersey. It functions as a clue to the show’s literary inspiration rather than as evidence that the character resides in the United Kingdom.

The letter matters: 221B is Holmes’s canonical address, while 221A is a different designation. The reference is not to House’s hospital address, and it should not be confused with the fictional Simpson family home at 742 Evergreen Terrace.