Which fictional address does Gregory House use in House, M.D.?

Gregory House uses the fictional address 221B Baker Street in House, M.D.

The address is a direct reference to 221B Baker Street, the London home traditionally associated with Sherlock Holmes. House was consciously modeled in part on Holmes, and the shared address is one of the show’s clearest literary clues.

House’s apartment address appears in the series as a character detail rather than as the setting for most medical plots. The show’s primary workplace is Princeton-Plainsboro Teaching Hospital, while House’s apartment represents his private life and his isolation from ordinary social routines.

The address should not be confused with 221A Baker Street, another fictional variation used in adaptations and fan references. In the Sherlock Holmes tradition and in House, M.D.’s reference, the identifying form is 221B.