Which fictional address does Gregory House use in House M.D. as a Sherlock Holmes reference?

Gregory House uses the fictional address 221B Baker Street in House M.D. as a Sherlock Holmes reference.

House is deliberately modeled in part on Sherlock Holmes, the detective created by Arthur Conan Doyle. The address 221B Baker Street is Holmes’s famous London residence, so the reference reinforces the connection between medical diagnosis and detective work.

The show includes several Holmes-related parallels beyond the address. House and Wilson reflect aspects of Holmes and Watson, and House’s methods rely on observation, deduction, and solving apparently impossible cases.

House’s actual apartment is presented through the series’ fictional setting rather than as a real New Jersey location. The address is therefore an intentional literary homage, not a claim that House lives in London.