Which doctor has a sister named Amelia Shepherd?

The doctor who has a sister named Amelia Shepherd is Derek Shepherd.

Amelia is the youngest of the Shepherd siblings and, like Derek, becomes a highly skilled neurosurgeon. Her character first appeared in the Grey’s Anatomy universe through the spin-off Private Practice, where she was connected to Derek’s former wife, Addison Montgomery.

Amelia eventually joins Grey’s Anatomy as a recurring character and later becomes a series regular. Her relationship with Derek is complicated by family trauma, professional rivalry, and Amelia’s history with addiction, but the two also share a deep understanding as surgeons. Amelia later takes over Derek’s former leadership role in neurosurgery at Grey Sloan Memorial Hospital.