Which disease does Remy Hadley have in House M.D.?

In House M.D., Remy Hadley has Huntington’s disease.

Huntington’s disease is an inherited neurodegenerative disorder caused by a mutation in the HTT gene. It can affect movement, cognition, and mood, and symptoms typically develop during adulthood. In the series, Remy Hadley, known as Thirteen, learns that she carries the disease.

Thirteen’s diagnosis becomes one of the show’s most significant long-running personal storylines. Her mother also has Huntington’s disease, and Thirteen faces the emotional and ethical consequences of knowing her own future risk and eventual prognosis.

The storyline is fictional, but Huntington’s disease is a real autosomal dominant condition: a person with one affected parent has a 50 percent chance of inheriting the altered gene. The show uses Thirteen’s experience to explore uncertainty, medical testing, caregiving, and decisions about reproduction.