Which classic detective inspired Gregory House's character in House M.D.?

Sherlock Holmes inspired Gregory House's character in House M.D.

The parallel is built into the character's name, methods, and relationships. “Holmes” and “House” are related English words, and both characters rely on observation, deduction, and unusual interpretations of evidence to solve puzzles that defeat others.

House's friend James Wilson occupies a role broadly comparable to Dr. John Watson, Holmes's companion and narrative counterpoint. The show also uses details such as House's apartment number, 221B, as a direct reference to Holmes's famous London address at 221B Baker Street.

House is not a simple modern retelling of the detective stories. His cases are medical rather than criminal, and his drug dependence, hospital position, and difficult relationships give him a distinct biography. The Holmes connection is an intentional influence that helps explain the series' mystery-solving format.