Which character’s death is shown in the House M.D. episode “Wilson’s Heart”?

Amber Volakis dies in the House M.D. episode “Wilson’s Heart.”

Amber, played by Anne Dudek, is injured in a bus accident after leaving a bar with Gregory House. The episode reveals that she had been taking amantadine, which her body could not safely process after her kidneys were damaged in the crash.

Because Amber’s kidneys fail, the drug causes fatal toxicity. House and the medical team initially investigate several possible diagnoses, but the combination of the accident, medication, and organ failure ultimately explains her condition. Wilson remains at her side as her condition becomes irreversible.

Amber’s death is especially important because it reshapes the relationship between House and Wilson. Wilson blames House for the circumstances leading to the accident, creating a major rupture between them. The episode is the second part of a two-part fourth-season finale, following “House’s Head.”