Which character is revealed to have died at the end of House M.D. season 4?

Amber Volakis is revealed to have died at the end of House M.D. season 4.

Her death occurs in the two-part finale “House’s Head” and “Wilson’s Heart.” Amber, played by Anne Dudek, had been one of the applicants competing for a place on House’s diagnostic team. Her aggressive ambition earned her the nickname “Cutthroat Bitch,” but the storyline also developed her relationship with James Wilson.

Amber is fatally injured after accompanying an intoxicated House on a bus. She has been taking amantadine, a drug that cannot be properly cleared because she has lost both kidneys. After the crash, the medication causes severe toxicity, and doctors cannot save her. House’s damaged memory makes the diagnosis and the sequence of events a central mystery across the two episodes.

The storyline profoundly affects Wilson and House. It also demonstrates the show’s recurring idea that solving a diagnosis does not always mean a patient can be saved. Amber’s death remains one of the series’ most consequential turning points.