Which character in House, M.D. is modeled after Sherlock Holmes?

Gregory House is the House, M.D. character modeled after Sherlock Holmes.

The connection appears in several details: House solves medical mysteries through deduction, lives at 221B Baker Street, plays with the initials of Holmes’s name, and has a confidant relationship with James Wilson that echoes Holmes and Dr. Watson. House’s surname also directly recalls Holmes’s residence and literary identity.

The resemblance is an adaptation framework rather than a claim that House is literally Sherlock Holmes. The series transfers detective fiction’s clues, red herrings, and final explanations into clinical diagnosis. Symptoms function like evidence, while House’s team tests competing theories.

The parallels sometimes lead viewers to identify Wilson as a direct copy of Watson in every respect, but the characters are not identical. Wilson is an oncologist and House’s friend, while Watson is a doctor and Holmes’s narrative companion in Arthur Conan Doyle’s stories.