Which actress portrays Lexie Grey on Grey's Anatomy?

Chyler Leigh portrays Lexie Grey on Grey’s Anatomy. Lexie is introduced as Meredith Grey’s younger half-sister and becomes one of the show’s most recognizable surgical residents.

Lexie first appears near the end of Season 3 and becomes a series regular from Season 4 through Season 8. Her character is known for an exceptional memory, earning the nickname “Lexipedia,” while also struggling with emotional awkwardness and the intense pressures of hospital training.

Her central relationships include her evolving bond with Meredith and her on-again, off-again romance with plastic surgeon Mark Sloan, played by Eric Dane. Lexie and Mark are critically injured in the Season 8 finale’s plane crash, and their deaths lead to the hospital’s renaming as Grey-Sloan Memorial Hospital.

The character’s full name is Alexandra Caroline Grey, but “Lexie” is the name used throughout the series. Chyler Leigh also reprised the role in a later special guest appearance, which is why her association with the character extends beyond Lexie’s original regular run.