Which 1959 suspense film starring Cary Grant and Eva Marie Saint involves a cross-country chase?

The 1959 suspense film starring Cary Grant and Eva Marie Saint involving a cross-country chase is North by Northwest.

Directed by Alfred Hitchcock, North by Northwest stars Cary Grant as Roger Thornhill, an advertising executive mistaken for a government agent. After being targeted by a criminal organization, Thornhill is forced into a flight across the United States while trying to discover why he has been framed.

Eva Marie Saint plays Eve Kendall, a glamorous and seemingly mysterious woman whose loyalties are initially uncertain. The film combines mistaken identity, espionage, romance, and chase sequences, including the celebrated pursuit involving a crop-dusting airplane and the climax at Mount Rushmore.

The screenplay was written by Ernest Lehman, who envisioned it as “the Hitchcock picture to end all Hitchcock pictures.” It is sometimes confused with Hitchcock’s earlier The Man Who Knew Too Much, another suspense story involving international danger, or To Catch a Thief, which also stars Cary Grant. North by Northwest is distinguished by its deliberately nationwide chase and its wrong-man spy plot.