Which 1926 Pulitzer-winning novel was written by Sinclair Lewis?

Arrowsmith was the 1926 Pulitzer-winning novel written by Sinclair Lewis.

Published in 1925, Arrowsmith follows Martin Arrowsmith, a physician and medical researcher whose career brings him into conflict with commercial pressures, institutional politics, and scientific responsibility. Lewis developed the story with help from the science writer Paul de Kruif.

The novel is notable for treating medicine and research as serious social subjects rather than simply using them as background. Its central conflict concerns whether scientific work should serve public health, personal ambition, or commercial interests.

Lewis declined the Pulitzer Prize, saying that he did not wish to accept an award based on official literary judgment. He later became the first American to receive the Nobel Prize in Literature, in 1930. His other major novels include Main Street, Babbitt, and Elmer Gantry.