When did House M.D. first premiere on television?

House M.D. first premiered on television on November 16, 2004. The medical drama debuted on Fox in the United States, introducing Gregory House and his diagnostic team at Princeton-Plainsboro Teaching Hospital.

The premiere episode, “Everybody Lies,” established the show’s central format: a puzzling medical case, a team of specialists, and House’s unconventional deductions. The series was created by David Shore and developed with a strong emphasis on mystery storytelling.

The program quickly became one of Fox’s major scripted hits. Although its hospital is fictional, many cases were inspired by unusual real medical conditions and historical medical reports. The show’s international broadcasts often followed different schedules, but the U.S. premiere date remains the standard reference date.

House M.D. later ran for eight seasons and ended in 2012, making its 2004 debut the beginning of an unusually long television run for a medical mystery series.