When did House M.D. first premiere on Fox?

House M.D. first premiered on Fox on November 16, 2004.

The medical drama debuted in the United States with the episode “Pilot,” introducing Gregory House, a brilliant but abrasive diagnostician who leads a team at the fictional Princeton-Plainsboro Teaching Hospital. The series was created by David Shore and produced with Bryan Singer among its early executive producers.

House was initially scheduled as part of Fox’s 2004–05 television season. Its unusual focus on difficult diagnostic cases, rather than conventional emergency-room action, helped distinguish it from other medical dramas. The title character’s personality and investigative methods also drew comparisons with Sherlock Holmes.

The date is sometimes confused with the show’s international premieres, which occurred later and varied by country. November 16, 2004 refers to the original American broadcast on Fox. The series continued for eight seasons before its finale aired in 2012.