What was the title of House M.D.’s 100th episode, which aired during season five?

House M.D.’s 100th episode was titled “The Greater Good.”

The episode aired during season five and centers on a woman whose decision to donate a kidney leads to a difficult medical investigation. As the team works through the case, the story examines altruism, personal motives, and the tension between helping others and protecting oneself.

“The Greater Good” marked a production milestone for the series. House M.D. reached 100 episodes during its fifth season, demonstrating the show’s established place in Fox’s schedule and its substantial international audience. Milestone episodes often receive special attention, but this one remains a regular medical drama story rather than a separate finale or documentary.

The title is sometimes confused with other season-five episodes, including “Unfaithful,” “Birthmarks,” and “Locked In.” Those are distinct installments. “The Greater Good” is the specific episode associated with the show’s 100th-episode milestone.