House’s prescription painkiller in House M.D. was Vicodin.
Vicodin is a brand name for a combination of hydrocodone and paracetamol, also called acetaminophen. In the United States, the medication was widely prescribed for pain, although its opioid component carries a risk of dependence and misuse.
In the series, House takes Vicodin to manage chronic leg pain caused by an infarction in his quadriceps muscle. His reliance on the drug becomes a major part of his personal storyline and repeatedly affects his medical practice, relationships, and employment.
The show's portrayal of Vicodin is fictionalized for drama and should not be treated as medical advice. House's pain, addiction, and treatment are story elements rather than a general model for managing chronic pain.