What was the name of House’s hospital apartment address, echoing Sherlock Holmes?

House’s apartment address in House M.D. was 221B Baker Street.

The address is a direct allusion to Sherlock Holmes, who famously lives at 221B Baker Street in Arthur Conan Doyle’s stories. Gregory House is designed as a modern medical counterpart to Holmes: both are exceptionally analytical, skeptical investigators whose cases depend on clues, deductions, and concealed motives. House’s friend James Wilson also parallels Dr. John Watson.

In the series, 221B is associated with House’s apartment in New Jersey rather than with London. The reference is one of several Holmes connections built into the character and show, including the similarity between “House” and “Holmes,” House’s use of deduction, and the importance of Wilson as his closest companion.

The letter matters: 221B is the canonical Holmes address, not 221A. Other famous fictional addresses, such as 42 Wallaby Way from Finding Nemo, belong to unrelated characters and are not part of House M.D.’s literary coding.