What was the final episode of House M.D.’s first season called?

The final episode of House M.D.’s first season was called “Honeymoon.” It is the 22nd episode of season one and originally aired on May 24, 2005.

The episode follows a patient whose case becomes especially significant because of the patient’s relationship to Dr. Lisa Cuddy. As with many early House episodes, the medical mystery develops through competing diagnoses, tests, and House’s willingness to pursue possibilities that other doctors reject.

“Honeymoon” also advances the personal relationships among House, Wilson, and Cuddy. The title refers to the patient’s circumstances rather than serving as a generic description of the entire series. The episode helped establish the show’s balance between a self-contained case and continuing character stories.

It is easy to confuse the season-one finale with “Three Stories,” the acclaimed 21st episode, or with “Everybody Dies,” the series finale. “Honeymoon” specifically closes the show’s first season.