What term describes the opposite orientation of the two DNA strands?
Answer
Antiparallel
Answer
Antiparallel
What term describes the opposite orientation of the two DNA strands? The strands are antiparallel.
In a DNA double helix, one strand runs from 5′ to 3′ while its partner runs from 3′ to 5′. The strands lie alongside one another, but their sugar-phosphate backbones point in opposite chemical directions. This arrangement is called antiparallel orientation.
Antiparallelism helps explain both DNA structure and replication. Complementary bases can form the familiar hydrogen-bonding patterns of A–T and G–C when the strands are aligned this way. During replication, the opposite orientations force one new strand to be synthesized continuously and the other discontinuously as Okazaki fragments.
A frequent mistake is to interpret “parallel” as meaning that the strands are not side by side. They are parallel in the everyday geometric sense, but antiparallel in molecular direction. The 5′ and 3′ labels refer to carbon positions in the deoxyribose sugar, not to the order of bases alphabetically or spatial distance along the helix.
Source: Wikipedia · fact-checked Aug. 2026