What song serves as the main title theme of House M.D.?

“Teardrop” by Massive Attack serves as the main title theme of House M.D. The song plays over the show's opening title sequence in the original broadcast version.

“Teardrop” was released by Massive Attack in 1998 as a single from the album Mezzanine. Its distinctive vocal performance was provided by Elizabeth Fraser of the Cocteau Twins. The track's atmospheric sound helped establish the series' tense, cerebral tone before each medical mystery began.

International broadcasts and some later versions used alternate music or shortened title sequences, which can cause confusion about the show's theme. The American opening credits are especially associated with “Teardrop,” but the song is not an original composition written solely for House M.D. It predated the series by several years.