What Sherlock Holmes-inspired street address does Gregory House use in House M.D.?

Gregory House uses the Sherlock Holmes-inspired address 221B Baker Street in House M.D.

The address is a direct reference to 221B Baker Street, the fictional London home of Sherlock Holmes in Arthur Conan Doyle’s stories. House is modeled in several ways on Holmes: both are brilliant investigators, both rely on deduction, and both can be dismissive of ordinary social conventions. James Wilson also broadly parallels Dr. Watson as the friend who understands and challenges the central investigator.

House’s address appears as part of the show’s network of Holmes references. His surname itself resembles “Holmes” in its association with a dwelling, while Wilson’s name echoes Watson’s role without being an exact counterpart. The references are influences rather than a claim that House is literally Holmes in a modern medical setting.

The address can be confused with real postal locations in London, where 221B Baker Street became associated with the Sherlock Holmes Museum. In House M.D., however, it is a fictional character detail used to underline the detective-story design of the medical drama.