What Sherlock Holmes address is associated with Dr. House in House M.D.?

Dr. House is associated with the Sherlock Holmes address 221B Baker Street.

The address appears as House’s apartment number in the series, directly linking the character to Arthur Conan Doyle’s detective. Sherlock Holmes famously lives at 221B Baker Street in London, where he shares rooms with Dr. John Watson. House’s apartment address is one of several deliberate Holmes references in House M.D.

The connection also appears in character design and story structure. House solves medical mysteries through observation and deduction, while James Wilson serves as a counterpart to Watson. House’s name itself echoes “Holmes,” and his dependence on Vicodin parallels Holmes’s use of cocaine and morphine in the original stories, though the television character’s addiction is treated as a serious medical and personal problem.

The fictional address should not be confused with an ordinary residential location. The real 221B Baker Street in London is associated with the Sherlock Holmes Museum, while House M.D. uses the number as an homage rather than claiming that House lives in London.