House is addicted to Vicodin in House M.D.
Vicodin is a prescription combination of hydrocodone and paracetamol, also known as acetaminophen. In the series, House uses it to manage chronic pain from the infarction that damaged his leg, but his use develops into a major addiction and a recurring source of conflict.
The medication is not simply a character prop. House’s dependence affects his judgment, relationships, employment, and treatment choices, and several storylines examine withdrawal, rehabilitation, relapse, and the consequences of concealing drug use.
Vicodin is often confused with other opioid pain medicines, including OxyContin and Percocet. Those are different products, even though all can be discussed in the broader context of prescription opioid use. The show’s depiction is fictionalized and should not be treated as medical guidance.