Gregory House commonly calls James Wilson “Wilson” in House M.D.
The surname is more than a casual form of address: it reinforces the show’s deliberate parallel between House and Sherlock Holmes. Wilson corresponds broadly to Dr. John Watson, the friend and observer who remains close to the brilliant but difficult investigator. The series makes the connection through their problem-solving partnership and contrasting personalities.
Wilson’s first name is James, and he is an oncologist at Princeton-Plainsboro. House usually uses his surname rather than “James,” which is why “Wilson” is the canonical short answer for the nickname question. The character’s friendship with House develops through arguments, practical help, and repeated attempts to keep House connected to ordinary human responsibilities.