Gregory House is famously addicted to Vicodin in House M.D. Vicodin is a brand name for a prescription combination of hydrocodone and paracetamol, also called acetaminophen.
Within the story, House uses the drug to manage chronic pain caused by an infarction in the quadriceps muscle of his right thigh. The medication reduces his pain but also contributes to dependence, impaired judgment, withdrawal, and repeated personal and professional crises.
House’s Vicodin use is not merely a character quirk. It is an ongoing plot issue that affects his relationships, medical decisions, employment, and treatment. The show repeatedly distinguishes between pain relief and addiction while dramatizing the consequences of long-term opioid use.
Viewers sometimes name a generic opioid rather than the specific fictional brand used most often in the series. The canonical answer connected to House is Vicodin, though the show also depicts other substances and treatment attempts.