What medical specialty did House’s original team primarily practice within at Princeton-Plainsboro?

House’s original team primarily practiced diagnostic medicine within Princeton-Plainsboro Teaching Hospital.

The Diagnostic Medicine department handles unusual or unexplained cases that have resisted ordinary treatment. Dr. Gregory House leads the team, assigning investigations and challenging proposed explanations until the group reaches a workable diagnosis. This department is the organizing premise of the series and explains why the characters regularly encounter rare diseases and medically complex patients.

House himself is described as a specialist in infectious disease and nephrology, but the team’s hospital role is diagnostic medicine. That distinction matters because the show often moves across multiple specialties while the team investigates one case. The department’s work is therefore broader than any single organ system or treatment area.

Some viewers identify House’s specialty as the answer because it is closely associated with his character. However, the question asks what the original team practiced as a department. Its canonical designation was Diagnostic Medicine, making that the more precise answer.