What London address does House M.D. use as a reference to Sherlock Holmes?

House M.D. references Sherlock Holmes through the London address 221B Baker Street.

Gregory House is deliberately modeled on Holmes in several ways: both are brilliant investigators, both use drugs, both have abrasive personalities, and both solve cases through observation and deduction. House’s first name also echoes Holmes’s associate Dr. John Watson through his friend James Wilson, whose initials are J.W.

In the series, House’s apartment is identified with the address 221B Baker Street. The address is famous as Sherlock Holmes’s fictional home in Arthur Conan Doyle’s stories.

The reference is not a claim that House lives in London. The series is set primarily in New Jersey, and the address functions as an allusion to the literary detective rather than as a realistic location for the hospital drama.