House M.D. consists of 177 episodes.
The total covers eight seasons broadcast by Fox from 2004 through 2012. Episodes generally use a medical-mystery format: House and his colleagues investigate a difficult case, test competing explanations, and revise their diagnosis as new evidence appears.
The count includes the two-part series finale, “Everybody Dies,” which was broadcast as the closing episode of season eight. Episode totals can vary in informal lists when specials, previews, or international scheduling packages are counted separately, but 177 is the standard series total.
House M.D. was also notable for maintaining a largely episodic structure while developing long-running stories about addiction, professional ethics, friendship, and the hospital staff. The episode count therefore represents both standalone diagnostic plots and continuing character arcs rather than 177 identical cases.