What is the title of the House M.D. season 4 finale about Amber Volakis?

The story behind the answer

The House M.D. season 4 finale about Amber Volakis is titled “Wilson's Heart.” It is the second part of a two-episode story that follows the events of “House's Head.”

In the episode, House tries to reconstruct what happened after a bus accident while Amber, Wilson's girlfriend, is critically ill. The medical mystery and the personal consequences are connected through House's missing memories and Wilson's relationship with Amber.

The title emphasizes Wilson's emotional stake rather than naming the medical diagnosis. Amber's illness involves amantadine toxicity after treatment for influenza, with complications that lead to severe organ failure.

The episode aired in 2008 and is widely regarded as one of the series' major dramatic turning points. It is commonly confused with “House's Head,” the preceding episode, but “Wilson's Heart” is the season-ending title.

Source: Wikipedia · fact-checked Oct. 2026

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