What is the title of the House M.D. episode that ends season 4 with Amber’s death?

“Wilson’s Heart” is the House M.D. episode that ends season 4 with Amber’s death. It aired on May 19, 2008, as the second part of a two-episode storyline that begins with “House’s Head.”

The story follows House after he wakes with a head injury and cannot remember the events leading to Amber’s medical crisis. The investigation gradually reconstructs what happened, while Wilson confronts the possibility that his partner may not survive.

Amber Volakis, played by Anne Dudek, had been a competitive doctor on House’s team and later became Wilson’s girlfriend. Her poisoning by amantadine, after she accompanied an intoxicated House, creates the episode’s central medical and emotional conflict.

The title emphasizes Wilson rather than House because the episode focuses on Wilson’s grief and loyalty. “House’s Head” and “Wilson’s Heart” are often treated as a paired finale, but only “Wilson’s Heart” contains the season-ending death.