The House M.D. episode in which House is shot by a former patient is titled “No Reason.” It is the 24th and final episode of the show’s second season and originally aired on Fox on May 23, 2006.
In the episode, a former patient named Jack Moriarty enters Princeton-Plainsboro and shoots House. The injury and medication that follows lead House into a surreal, psychologically intense sequence in which he questions what is real and reexamines his own choices.
The title refers to the mystery surrounding Moriarty’s motive and to the episode’s broader exploration of explanations, perception, and certainty. The story is not presented as a straightforward hospital case, making it one of the series’ more experimental season finales.
“No Reason” is sometimes confused with “Last Resort,” another House M.D. episode involving a gunman and hostages. “Last Resort” occurs later, in season five, while “No Reason” is the season-two finale involving House’s shooting.