What is the title of the House, M.D. episode in which Amber Volakis dies?

“Wilson’s Heart” is the House, M.D. episode in which Amber Volakis dies.

It is the second part of a two-part season-four finale, following “House’s Head.” The story begins after a bus accident leaves Gregory House with amnesia and a missing stretch of memory. As doctors reconstruct what happened, they discover that Amber was critically injured and had been exposed to amantadine, a medication that becomes central to the medical explanation.

Amber is James Wilson’s partner, so the episode’s medical crisis also becomes a major emotional turning point for Wilson and House. Her death profoundly affects their friendship and contributes to later storylines involving grief, guilt, and House’s self-destructive behavior.

The title is often mixed up with “House’s Head,” which sets up the mystery but does not contain the death’s conclusion. “Wilson’s Heart” originally aired in 2008 and is widely regarded as one of the series’ major dramatic episodes.