The season-four premiere of House M.D. is titled “Alone.”
The episode first aired in September 2007 and follows Gregory House as he attempts to handle a difficult case without his former diagnostic team. The episode reflects the major staffing transition that begins the fourth season.
House eventually conducts a competitive process to select new fellows. This extended recruitment storyline introduces doctors who become important members of the diagnostic department, including Remy Hadley, Chris Taub, and Lawrence Kutner.
“Alone” is not the series finale or the title of a later character-centered episode. It specifically opens season four and establishes the show’s new team-building structure. The episode was written by Peter Blake and directed by Katie Jacobs.