What is the title of House M.D.’s fourth-season finale about Wilson’s personal crisis?

“Wilson’s Heart” is the title of House M.D.’s fourth-season finale about Wilson’s personal crisis.

The episode originally aired on May 19, 2008, as the second part of a two-part finale. It follows the aftermath of House’s unexplained bus accident and the effort to determine what happened to Amber Volakis, who was traveling with him. The medical mystery becomes inseparable from Wilson’s relationship with Amber.

Robert Sean Leonard played James Wilson, while Anne Dudek played Amber. The episode uses House’s fragmented memories and diagnostic reasoning to reconstruct the events surrounding the accident. Its emotional focus is Wilson’s grief and the consequences for his friendship with House.

“Wilson’s Heart” is frequently paired with “House’s Head,” the preceding episode. The two titles form a connected story rather than two unrelated cases. The finale is also remembered for its use of music and for changing the relationships among House, Wilson, and Amber.