What is the surname of House’s friend James, played by Robert Sean Leonard, in House M.D.?

The story behind the answer

James Wilson’s surname is Wilson in House M.D.

Dr. James Evan Wilson is an oncologist at Princeton-Plainsboro and Gregory House’s closest friend. Robert Sean Leonard played him throughout the series. Wilson’s professional specialty frequently brings him into contact with seriously ill patients, while his friendship with House places him at the center of many personal and ethical storylines.

Wilson and House are opposites in several ways. Wilson is more diplomatic and emotionally open, whereas House is abrasive and suspicious. Nevertheless, Wilson understands House better than most colleagues and repeatedly helps him navigate crises. Their bond is one of the show’s defining relationships.

The name can be confused with other recurring surnames because the hospital contains several doctors who work closely with House. Wilson is not House’s supervisor or department head; Lisa Cuddy holds the major hospital administration role. Wilson’s full name is James Evan Wilson, but “Wilson” is the single canonical surname requested here.

Source: Wikipedia · fact-checked Oct. 2026

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