James Wilson's surname in House M.D. is Wilson.
Dr. James Evan Wilson is an oncologist at Princeton-Plainsboro Teaching Hospital and one of Gregory House's closest friends. Robert Sean Leonard played Wilson throughout the series, making the character a consistent counterbalance to House's confrontational personality and unconventional methods.
Wilson is generally more empathetic and socially diplomatic than House, but he is not simply a passive companion. His storylines examine professional responsibility, marriage, friendship, grief, and the emotional burdens of treating cancer patients. His long friendship with House is central to the series' personal drama.
Viewers sometimes confuse Wilson's role with that of hospital administrators or House's diagnostic colleagues. Wilson is specifically an oncologist, meaning his specialty concerns cancer and related diseases. His surname also appears in the title of the series finale, “Everybody Dies,” which focuses heavily on the consequences of his illness and his relationship with House.