The surname of Dr. Gregory House’s friend James in House M.D. is Wilson.
James Wilson is one of the series’ most important supporting characters and is played by Robert Sean Leonard. He works as an oncologist at Princeton-Plainsboro and has a long friendship with House. Wilson’s calm, empathetic style contrasts with House’s confrontational manner, but Wilson is not simply a passive companion: he frequently challenges House’s choices and accepts difficult consequences for doing so.
The character’s full name is James Evan Wilson. His initials and narrative role contribute to the show’s broader Sherlock Holmes influence, with Wilson serving as a counterpart to Dr. John Watson. The connection is an allusion rather than a direct adaptation of the original detective stories.
The surname can be confused with “Foreman,” “Chase,” or “Cuddy,” all of which belong to other major characters. Wilson is the oncologist and House’s closest friend, while Eric Foreman and Robert Chase are doctors who work on House’s diagnostic teams.