What is the name of the House M.D. episode featuring the death of Amber Volakis?

Wilson's Heart is the House M.D. episode featuring the death of Amber Volakis.

It is the twenty-third episode of the show's fourth season and follows House after a bus accident leaves him with missing memories. As Wilson's girlfriend Amber deteriorates from amantadine toxicity, House tries to reconstruct the events that led to the accident and identify the cause of her condition.

The episode concludes a two-part story that begins with House's Head. Amber had been a member of House's temporary diagnostic team and later became romantically involved with James Wilson. Her death has lasting consequences for Wilson and for House's understanding of responsibility and friendship.

The title is significant because Wilson is central to the emotional consequences of the case. Viewers sometimes identify House's Head as the episode containing the death, but that installment establishes the mystery; Wilson's Heart delivers the medical and emotional conclusion.