What is the name of House's best friend in the TV series House M.D.?

James Wilson is House's best friend in House M.D.

Dr. James Wilson is an oncologist at Princeton-Plainsboro Teaching Hospital and is played by Robert Sean Leonard. Although House often mocks Wilson's empathy and concern for other people, Wilson remains one of the few characters who consistently understands House and confronts his behavior.

Their friendship is loosely modeled on the relationship between Sherlock Holmes and Dr. John Watson. Like Watson, Wilson serves as a trusted companion and a moral counterweight, while House uses deduction and provocation to solve problems. The show adapts that relationship to a modern hospital setting.

Wilson's importance grows throughout the series. He supports House during professional crises, romantic failures, and addiction-related problems. In the final season, Wilson's terminal illness becomes the central reason for House's final major decision and shapes the emotional ending of the series.