What is the largest margin of victory in an NFL game?

The largest margin of victory in an NFL game is 73 points. The Chicago Bears defeated the Washington Redskins 73–0 in the 1940 NFL Championship Game, played on December 8, 1940, at Griffith Stadium in Washington, D.C.

Chicago scored 11 touchdowns and shut out Washington completely. The Bears led 28–0 at halftime, then added 26 points in the third quarter and 19 in the fourth. Bill Osmanski scored on a 68-yard touchdown run early in the game, and the Bears' defense repeatedly turned Washington possessions into scoring opportunities.

The result was remarkable because Washington entered the championship game with a 9–2 record, better than Chicago's 8–3 mark. The Bears' victory remains the most lopsided result in NFL history, including both regular-season and postseason games. It is also commonly remembered simply as “73–0.”

The record is for margin, not necessarily the highest total score by one team in every statistical category. For example, Washington later scored 72 points in a 72–41 regular-season victory over the New York Giants in 1966, but that win had a smaller 31-point margin.