What is the first name of House M.D.’s oncologist and House’s closest friend?

The story behind the answer

The first name of House M.D.’s oncologist and House’s closest friend is James.

Dr. James Wilson is an oncologist at Princeton-Plainsboro Teaching Hospital and one of the series’ most important supporting characters. Robert Sean Leonard plays Wilson, whose compassionate, patient-centered outlook frequently contrasts with House’s sarcasm and hostility toward social conventions.

Wilson and House have a long, complicated friendship. Wilson often acts as House’s confidant, moral counterweight, and source of practical support, even when House’s behavior causes serious problems. Their relationship is central to the show’s later emotional development and is especially important in the final season.

The character’s surname is Wilson, which also contributes to the show’s Sherlock Holmes parallel: Wilson occupies a role broadly comparable to Dr. Watson. However, the requested first name is James, not the actor’s name or the name of another physician on House’s team.

Source: Wikipedia · fact-checked Oct. 2026

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