What is House’s apartment number in House M.D.?

House’s apartment number in House M.D. is 221B.

Gregory House lives in apartment 221B at 221 Baker Street in the series. The address is a deliberate reference to 221B Baker Street, the fictional London home of Sherlock Holmes. House’s personality and investigative methods are also modeled partly on Holmes, making the apartment number one of the show’s clearest literary clues.

The apartment appears as a private setting where House plays music, takes medication, studies cases, and interacts with colleagues. It contrasts with the public, institutional environment of Princeton-Plainsboro Teaching Hospital and reveals aspects of House’s life outside medicine.

The address is fictional within the show and should not be confused with the real-world history of 221B Baker Street in London. The important House M.D. detail is the apartment designation: 221B, not merely the street name. This small reference is easy to miss because the show rarely explains it directly.