What fictional London address is associated with Gregory House in House M.D.?

Gregory House is associated with the fictional London address 221B Baker Street in House M.D.

The address is a deliberate reference to Sherlock Holmes, whose famous home is 221B Baker Street. House’s methods, personality, drug use, and friendship with James Wilson all contain parallels to Holmes stories, with Wilson serving as an analogue to Dr. John Watson.

In the series, House’s New Jersey apartment is identified as 221B Baker Street, creating an explicit link between the modern physician and the literary detective. The address is an homage rather than an indication that House lives in London; the show’s main setting remains Princeton-Plainsboro in New Jersey.

Some references list the apartment simply as 221B, while others emphasize the full street address. The important canonical clue is Baker Street, which makes the Holmes connection unmistakable.