What fictional address does Gregory House have in House M.D.?

Gregory House’s fictional address in House M.D. is 221B Baker Street. The apartment number is a deliberate reference to 221B Baker Street, the London home of Sherlock Holmes.

House is modeled in part on Holmes: both characters are brilliant, unconventional investigators who rely on close observation, deduction, and a trusted companion. James Wilson fills a Watson-like role in House’s personal and professional life, while House’s surname also resembles Holmes’s.

The series places House’s apartment in Princeton, New Jersey, rather than London. The address appears as a character detail and reinforces the show’s detective-story structure, in which medical symptoms function like clues.

The Holmes reference is easy to miss because the show is set in the United States and focuses on medicine rather than criminal investigations. The correct address is 221B Baker Street, not 221A, and it is the famous Holmes address rather than a real House residence.