What are Dr. House’s two medical specialties in House M.D.?

Dr. House’s two medical specialties in House M.D. are nephrology and infectious disease.

Nephrology is the medical specialty focused on the kidneys, while infectious disease concerns illnesses caused by pathogens such as bacteria, viruses, fungi, and parasites. House’s training in both areas helps explain his interest in complex systemic illnesses and unusual diagnostic patterns.

His hospital job is different from his specialties. House leads diagnostic medicine, a department created to investigate difficult cases, but he is described as a board-certified diagnostician with specialties in nephrology and infectious disease. The distinction matters because the series often shows him working across many fields.

Viewers sometimes answer “diagnostic medicine,” which identifies House’s department rather than his two personal specialties. Other characters also have defined specialties, including Wilson in oncology and Cameron in immunology, but those are not House’s specialties.