Gregory House’s apartment number in House M.D. is 221B. The address is a direct reference to 221B Baker Street, the fictional London residence of Sherlock Holmes.
The Holmes connection is intentional rather than incidental. House and Holmes are both analytical investigators who rely on observation, deduction, and unusual interpretations of evidence. Their names also echo one another: House resembles “Holmes,” while Wilson parallels Dr. Watson in the friendship dynamic.
House’s apartment is shown as a private space where his isolation, musical interests, drug use, and relationships are explored away from Princeton-Plainsboro. The address appears as part of the show’s broader pattern of literary references, not as a claim that House lives in London.
A common mix-up is to answer “221B Baker Street,” which is the complete Holmes reference. In the series, the requested apartment number is simply 221B; the fictional hospital and House’s apartment are separate locations.