On what date did the TV series House M.D. premiere in the United States?

House M.D. premiered in the United States on November 16, 2004.

The medical drama debuted on Fox and introduced Dr. Gregory House, a brilliant but abrasive diagnostician who leads a team at the fictional Princeton-Plainsboro Teaching Hospital. The series was created by David Shore and developed with executive producer Katie Jacobs and star Hugh Laurie.

The premiere episode, titled “Pilot,” establishes the show's central formula: House and his team investigate an unusual illness while navigating ethical disputes, hospital politics, and House's dependence on pain medication. The first season eventually became one of Fox's strongest scripted successes.

The date is sometimes confused with the show's later international premieres, which varied by country. It is also distinct from the date of the series finale, which aired in 2012 after eight seasons.