On what date did the first episode of House M.D. air?

The first episode of House M.D. aired on November 16, 2004, on the Fox network in the United States.

The premiere introduced Gregory House, a diagnostician at Princeton-Plainsboro Teaching Hospital, and established the series’ central format: a difficult medical case investigated through competing diagnoses and increasingly specialized tests. Hugh Laurie played House, supported by the first diagnostic team and hospital staff.

The date is sometimes confused with the show’s later finale date. House ended on May 21, 2012, after eight seasons, so those two dates mark opposite ends of the series’ original run.

The premiere launched a program that became one of Fox’s best-known dramas. Its mix of medical mystery, dark humor, workplace conflict, and serialized character development distinguished it from more conventional hospital shows.