On what date did House M.D. premiere on Fox?

House M.D. premiered on Fox on November 16, 2004. The first episode introduced Gregory House, his diagnostic team, and the fictional teaching hospital where the medical mysteries unfold.

The premiere episode is titled “Pilot.” It follows House and his team as they investigate the rapidly worsening illness of a kindergarten teacher. The episode established the program's recurring structure: symptoms create a difficult puzzle, the team tests competing diagnoses, and House challenges assumptions made by other physicians.

The show was created by David Shore and produced in association with Heel & Toe Films, Shore Z Productions, and Bad Hat Harry Productions. Bryan Singer directed the pilot, helping define the darkly humorous tone that became characteristic of the series.

The Fox premiere date is sometimes confused with the start of later international broadcasts or with the date of the show's final episode. House M.D. eventually ran for eight seasons, but its original United States television debut was in November 2004.