In which city was most of House M.D. filmed?

Most of House M.D. was filmed in Los Angeles.

Although the story is set at the fictional Princeton-Plainsboro Teaching Hospital in New Jersey, production took place primarily in Southern California. The University of California, Los Angeles campus supplied exterior shots used to represent the hospital and its surroundings.

The location difference is a common source of confusion. Princeton-Plainsboro is an invented New Jersey institution within the story, while Los Angeles was the real production base. The show’s visual design used locations and sets to create a consistent East Coast medical environment.

The series was produced for Fox and centered on Gregory House’s diagnostic department. Its fictional geography supports the plot, but filming geography refers to where the actors, crew, and cameras actually worked. Therefore, the answer is Los Angeles rather than Princeton or a real New Jersey hospital.